Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression After General Anesthesia
Comparative Study Between Efficacy of Dexmedetomidine, Magnesium Sulphate and Lidocaine for Cough Suppression During General Anesthetic Emergence
Al-Azhar University
300 participants
Jun 2, 2025
INTERVENTIONAL
Conditions
Summary
The aim of this prospective randomized controlled double-blinded study is to compare the efficacy of dexmedetomidine, MgSO4 and lidocaine for cough suppression during general anesthetic emergence as regard number and severity.
Eligibility
Inclusion Criteria6
- Aged 21-60 years.
- Both genders.
- Body mass index < 30 kg/ m2
- American Society of Anesthesiology (ASA) physical status I-II.
- Mallampati score class I or II.
- Patients undergoing surgery under general anesthesia.
Exclusion Criteria10
- Known allergy to study drugs.
- History of psychiatric illness.
- Patients with major organ diseases.
- Pre-existing neurological deficits.
- Body mass index >30 kg/m2.
- Active airway infection or history of tracheal and laryngeal surgery.
- Lower esophageal sphincter incompetence (and reflux).
- Increased intracranial and intraocular pressure.
- Use of cough-inducing medications
- Pregnant, and lactating women.
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Interventions
Patients will receive 0.5 μg/kg dexmedetomidine in 10ml normal saline 10 min before the end of surgery.
Patients will receive 30 mg/kg IV magnesium sulfate 50% 10 min before the end of surgery.
Patients will receive lidocaine 1.5 mg/kg lidocaine 10 min before the end of surgery.
Patients will receive 10 ml normal saline 10 min before the end of surgery.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06979141