Investigating Multigene Methylation Dynamics in Treatment Response Surveillance for Esophageal Carcinoma

This study is tracking changes in DNA methylation patterns (chemical tags on DNA that affect gene activity) in the blood of people being treated for esophageal cancer. The goal is to find new blood-based markers that can predict whether a patient is responding to treatment or if cancer is returning. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with esophageal cancer, confirmed by pathology, with complete medical records including staging - You have no signs of cancer spread to other organs (liver, lungs, bones) - You have not previously had esophageal surgery, chemotherapy, chest radiation, or immunotherapy **You may NOT be eligible if...** - Your life expectancy is less than 6 months - You have a serious cognitive or psychiatric condition that affects your ability to participate - You have previously had cancer at another site (except cured skin cancers or carcinoma in situ) Talk to your doctor to see if this trial is right for you.