Acetazolamide in Persons With Type 1 Diabetes - Crossover Trial

This study is investigating whether a drug called acetazolamide (commonly used for altitude sickness and glaucoma) can affect blood sugar levels and kidney function in people with type 1 diabetes. It is a crossover trial, meaning each participant will try both the drug and a placebo at different times. **You may be eligible if...** - You are 18 or older with a confirmed diagnosis of type 1 diabetes - Your diabetes treatment has been stable for at least 3 months - Your kidney function is adequate (eGFR of at least 45) - Your blood bicarbonate level is normal (at least 24 meq/L) - You are willing to use contraception during the entire study **You may NOT be eligible if...** - You have an allergy to acetazolamide or similar drugs (carbonic anhydrase inhibitors) - You have liver disease or drink heavily (more than 14 drinks per week) - You have a positive urine drug screen - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.