RecruitingNot ApplicableNCT06982209

ANI-Guided Anesthetic Desflurane Consumption

Analgesia/Nociception Index (ANI)-Guided Desflurane Titration Reduces Anesthetic Consumption in Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial

Sponsor

Wonkwang University Hospital

Enrollment

125 participants

Start Date

Jul 2, 2026

Study Type

INTERVENTIONAL

Conditions

Postoperative Pain General Anesthesia Laparoscopic Cholecystectomy

Summary

General anesthesia requires precise titration of inhaled anesthetics like desflurane and opioids like remifentanil to balance sedation, analgesia, and hemodynamic stability. The Analgesia/Nociception Index (ANI), derived from heart rate variability (HRV), quantifies parasympathetic tone to assess nociception-antinociception balance on a 0-100 scale, with lower values indicating nociceptive stress. ANI analyzes high-frequency HRV components, reflecting parasympathetic inhibition during painful stimuli, making it a reliable indicator of intraoperative nociception. Studies validate the utility of ANI in detecting nociceptive events during laparoscopic surgery. ANI-guided opioid titration reduces opioid consumption and stabilizes hemodynamics, enhancing perioperative outcomes.

Eligibility

Min Age: 19 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a medical device called Analgesia/Nociception Index (ANI) for people with general anesthesia, laparoscopic cholecystectomy, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 19 Years to 65 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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