High Dose Rate (HDR) Brachytherapy Salvage After Prostatectomy

This study is testing a type of targeted radiation treatment called high dose rate (HDR) brachytherapy for men with prostate cancer that has come back in the prostate bed (where the prostate used to be) after having their prostate surgically removed. Brachytherapy involves placing tiny radioactive seeds or a probe very precisely inside the body to deliver a high dose of radiation directly to the tumor. **You may be eligible if...** - You have had your prostate surgically removed and your PSA (a blood marker for prostate cancer) is rising again - A PET scan (PSMA or choline) and MRI show that the cancer is isolated to the prostate bed — no spread elsewhere - The recurrent tumor can be seen on ultrasound for accurate placement of the radiation probe **You may NOT be eligible if...** - Your cancer has spread to distant locations (other organs or bones) - Cancer has only recurred in lymph nodes (not the prostate bed) - The prostate bed area has already been irradiated previously - Cancer is in multiple separate spots (not isolated) - You have a life expectancy of less than 5 years or cannot tolerate the procedure Talk to your doctor to see if this trial is right for you.