RecruitingNot ApplicableNCT06986096

Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention

Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention, LIBRA-NET


Sponsor

Slovak Academy of Sciences

Enrollment

40 participants

Start Date

Sep 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Due to the increasing incidence of dementia and the lack of causal treatment, non-pharmacological interventions represent an attractive and effective therapeutic strategy of neurodegenerative diseases, such as Alzheimer's disease. The aim of the study is to assess the impact of a supervised 9-month intervention with aerobic-strength training and nutritional counseling compared to cognitive training and stretching on the brain, cognitive and motor functions, metabolism, physical fitnes and plasma markers of neurodegenertion in older adults at increased risk of developing Alzheimer's disease.


Eligibility

Min Age: 60 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a combined program of healthy eating and exercise can protect and improve brain health in people who are showing early signs of memory decline (subjective or mild cognitive impairment) and have early markers of Alzheimer's disease in their system. **You may be eligible if...** - You are a non-smoker - You have noticed memory concerns or have been diagnosed with mild cognitive impairment - Your doctor has identified certain biological markers in your body associated with early Alzheimer's disease - You are able to commit to the program without major scheduling conflicts **You may NOT be eligible if...** - You have severe heart, liver, or kidney disease - You have poorly controlled diabetes (HbA1c above 7%), especially if treated with insulin or incretin analogs - You have had cancer treated with chemotherapy or radiation within the last 5 years - You have another serious illness that would interfere with participation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALAerobic-strength training and nutritional counseling

The intervention consists of a structured program that includes aerobic-strength training (1h training, 3 times per week) conducted by professional trainers combined with nutritional counseling.

BEHAVIORALCognitive training and stretching.

The intervention consists of a structured program that includes cognitive training combined with stretching training (90mins training, 2x per week).


Locations(1)

Biomedical Research Center Slovak Academy of Sciences

Bratislava, Bratislava Region, Slovakia

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NCT06986096


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