Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI)
A Prospective, Randomized Controlled Trial Comparing Noninvasive Ventilation (NIV) Versus High-Velocity Nasal Cannula (HVNC) in the Management of Acute Post-Operative Respiratory Failure
Assiut University
180 participants
Jul 1, 2025
INTERVENTIONAL
Conditions
Summary
Postoperative respiratory failure (PORF) remains a critical driver of morbidity, mortality, and incremental care costs in surgical populations. Traditional escalation often involves invasive mechanical ventilation, which is associated with ventilator-associated pneumonia (VAP), prolonged intensive care unit (ICU) stays, and increased resource burden.
Eligibility
Inclusion Criteria4
- Age above 18 years
- within 48 hours after major surgery
- PAO2/FIO2 less than 200
- Signs of respiratory distress and respiratory rate (RR) more than 25 cycles/minute
Exclusion Criteria4
- Age below 18 years
- Pregnant ladies
- Orofacial trauma or burns
- Active Gastrointestinal bleeding
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Interventions
The second arm (NIV group) will be managed by BIPAP device for post-operative respiratory failure
The first arm (HVNC group) will be managed by Vapotherm device for post-operative respiratory failure
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06988111