Pioglitazone and Empagliflozin for Fatty Liver Disease in Type 2 Diabetes
Evaluation of Pioglitazone and Empagliflozin Combination Therapy in Type 2 Diabetes Patients With Metabolic Dysfunction-Associated Fatty Liver Disease
Seoul National University Bundang Hospital
120 participants
Jan 1, 2025
INTERVENTIONAL
Conditions
Summary
This exploratory study will assess the efficacy of combined pioglitazone and empagliflozin therapy in improving hepatic and metabolic outcomes in patients with type 2 diabetes mellitus and metabolic dysfunction-associated fatty liver disease (MAFLD). Although each agent has shown beneficial effects individually, evidence on their combined impact on liver health is scarce. This study seeks to determine whether the combination therapy yields additive improvements in hepatic steatosis, inflammation, and fibrosis, potentially offering a new therapeutic strategy for diabetic patients with fatty liver disease.
Eligibility
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Interventions
Participants will receive pioglitazone 15 mg, administered orally once daily. The tablet may be taken with or without food.
Participants will receive empagliflozin 10 mg, administered orally once daily. The tablet may be taken with or without food.
Participants will receive one tablet of pioglitazone 15 mg and one tablet of empagliflozin 10 mg, administered orally once daily. Both tablets may be taken with or without food.
Locations(1)
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NCT06989723