RecruitingPhase 1NCT06989957

Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)

Psilocybin and MDMA for Post-traumatic Stress Disorder (PTSD)


Sponsor

Johns Hopkins University

Enrollment

40 participants

Start Date

Sep 17, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to assess the safety and effectiveness of co-administered MDMA and psilocybin in military Veterans with a diagnosis of Posttraumatic Stress Disorder (PTSD). To apply or learn more, please view our website: https://hopkinspsychedelic.org/pamvet


Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether psilocybin (the active compound in 'magic mushrooms') and MDMA (sometimes known as 'ecstasy') can help military veterans recover from post-traumatic stress disorder (PTSD). **You may be eligible if...** - You are a military veteran aged 21 or older - You have a confirmed PTSD diagnosis lasting at least 6 months - You are medically stable and considered low risk for suicide - You have not previously used psilocybin or MDMA in anything beyond very small doses - You weigh between 40 kg and 120 kg **You may NOT be eligible if...** - You have a history of schizophrenia, psychosis, or bipolar I or II disorder - You have had a moderate or severe alcohol or drug use disorder in the past year - You have borderline personality disorder - You have a close family member with schizophrenia or psychotic disorders - You have significant suicidal thoughts in the past 6 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPsilocybin

Experimental Psilocybin (exact dosages not disclosed)

DRUGPsilocybin

Comparator Psilocybin (exact dosages not disclosed)

DRUGMDMA

Experimental MDMA (exact dosages not disclosed)

DRUGMDMA

Comparator MDMA (exact dosages not disclosed)


Locations(1)

Johns Hopkins Center for Psychedelic and Consciousness Research

Baltimore, Maryland, United States

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NCT06989957


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