Comparison of Needling and Microneedling Plus Phototherapy in Localized Vitiligo Patients
Puncture to Repigment: A Comparative Analysis Of Needling vs. Microneedling Along With NBUVB in Treatment of Non-Segmental Vitiligo
Khyber Teaching Hospital
80 participants
Mar 1, 2025
INTERVENTIONAL
Conditions
Summary
This randomized controlled trial aims to compare the efficacy of needling versus microneedling, both followed by narrowband UVB therapy, in achieving repigmentation in patients with localized stable non-segmental vitiligo.
Eligibility
Inclusion Criteria3
- Both male and female
- Age 15-60 years
- Patients having vitiligo for more than 1 year
Exclusion Criteria4
- Patients with tendency of keloid formation or hypertrophic scarring
- Patients with any bleeding disorder, coagulation defect or using anti platelets
- Any local infection at the treatment site
- Patients who had received systemic therapy in last 6 months
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Interventions
Participants in this arm will undergo needling using a sterile 30G (4mm) needle to manually puncture and implant melanocytes from perilesional pigmented skin into depigmented lesions. The procedure will be performed once every four weeks for a total of six sessions.
Participants in this arm will undergo microneedling using a Dermapen device with 1.5 mm needles to create controlled micro-injuries in depigmented skin to enhance melanocyte migration and repigmentation. This procedure will be performed once every four weeks for six sessions.
Locations(1)
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NCT06991972