RecruitingNot ApplicableNCT06992115

A Study of the MIND Diet for Persons With Multiple Sclerosis

Randomized Controlled Trial of MIND Diet for Neuroprotection and Symptom Management in MS

Sponsor

Icahn School of Medicine at Mount Sinai

Enrollment

100 participants

Start Date

May 12, 2025

Study Type

INTERVENTIONAL

Conditions

Multiple Sclerosis

Summary

This study will assess the impact of a MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet on brain health and MS symptoms. Participants will be randomly assigned to one of two arms: the diet intervention arm or the "continue current diet"/control arm. Participants randomized to the dietary intervention arm will change their diet to follow a MIND dietary pattern for one year; diet-related education and programming is provided to support this change. Participants randomized to the continue/control arm will be asked to continue their current dietary habits, without major change for one year; multiple sclerosis (MS) MS-related related education and programming (unrelated to diet) is provided. All participants will be asked to provide blood \& stool samples and to complete online questionnaires \& three in-person assessments.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether following the MIND diet — a brain-healthy eating pattern combining the Mediterranean and DASH diets — can slow disease progression and reduce inflammation in people with multiple sclerosis (MS). **You may be eligible if...** - You are 18–70 years old - You have been diagnosed with MS (any form, with or without treatment) - Your current diet scores low on the MIND diet scale (score of 8 or below at baseline) **You may NOT be eligible if...** - You have another neurodegenerative disease such as Alzheimer's, or a serious neurological condition like stroke - You have a serious medical condition that could affect your ability to participate (such as cancer or HIV) - You are pregnant or planning to become pregnant during the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BEHAVIORALMediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet

A dietary pattern which promotes the intake of olive oil, fish, leafy greens \& other vegetables, fruits, whole grains, and legumes, and discourages processed foods, red meat, and sugar.

BEHAVIORALSmall Group

Education and social support on topics related to multiple sclerosis such as disease-modifying therapies and MRI in MS.

Locations(1)

Mount Sinai Hospital

New York, New York, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06992115

Related Trials

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

NCT000012481 location

Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

NCT027842101 location

Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)?

NCT053577811 location

Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy

NCT058494671 location

Blood Flow Restriction for Upper Limb Rehabilitation in People With Multiple Sclerosis. A Randomized Controlled Trial (BFRT-EM)

NCT067952301 location