Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy

This study is using a new imaging technique called Brillouin microscopy to study the physical stiffness properties of the cornea (the clear front of the eye) in glaucoma patients, to understand if corneal stiffness plays a role in the disease. **You may be eligible if...** - You are 18 or older - You have been diagnosed with primary open-angle glaucoma (either high-pressure or normal-pressure type), OR you are a healthy age-matched volunteer without glaucoma - Your best-corrected vision is 20/25 or better - You have not had eye surgery or laser treatments **You may NOT be eligible if...** - You have corneal disease or other conditions affecting eye pressure readings - You have retinal diseases affecting vision (e.g., macular problems) - You have diabetes or uveitis (eye inflammation) - You have a neurodegenerative disease such as Alzheimer's, Parkinson's, or multiple sclerosis - You have moderate to severe glaucoma - You wear contact lenses Talk to your doctor to see if this trial is right for you.