Colchicine in Chronic Kidney Disease Patients

This study tests whether colchicine — an anti-inflammatory medication traditionally used for gout — can reduce the risk of cardiovascular events (such as heart attacks and strokes) in patients with moderate chronic kidney disease who have already had a prior heart or vascular event. **You may be eligible if...** - You are between 18 and 99 years old - You have moderate chronic kidney disease (eGFR 30–59 mL/min/1.73 m²) - You have a history of a cardiovascular event such as a heart attack, stroke, bypass surgery, or severe peripheral artery disease **You may NOT be eligible if...** - You have an allergy to colchicine or are already taking it - You have been hospitalized in the past 3 months - You have an active cancer (other than certain cured skin cancers) - You have liver cirrhosis (Child-Pugh B or C), active HIV, active hepatitis B or C - You have low blood counts, a stomach ulcer, or are pregnant or breastfeeding - You are taking certain antifungal or antiviral medications that interact with colchicine Talk to your doctor to see if this trial is right for you.