RecruitingPhase 4NCT07000526

Inhaled Sedation in Critically Ill Patients

Inhaled Sedation in Critically Ill Patients: a Multicentre Randomized Clinical Trial

Sponsor

Instituto de Investigación Hospital Universitario La Paz

Enrollment

620 participants

Start Date

Dec 15, 2025

Study Type

INTERVENTIONAL

Conditions

Sedation Airway Extubation

Summary

The proposal of this study is to compare inhaled sedation with isoflurane administered via the Sedaconda ACD-S system with intravenous sedation with propofol. Patients will be randomized 1:1 to receive either inhaled sedation with isoflurane administered via the Sedaconda ACD device (Sedana Medical, Uppsala, Sweden) or intravenous propofol. The primary endpoint is the number of ventilator-free days at 28 days after randomization.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Isoflurane and a drug called Propofol for people with airway extubation and sedation. The study is currently recruiting participants at 22 locations. People eligible for this study include aged 18 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGIsoflurane

Inhaled sedation with isoflurane via Sedaconda ACD-S

DRUGPropofol

Intravenous sedation with Propofol 20 mg/ml

Locations(22)

Hospital Vega Baja

Orihuela, Alicante, Spain

Hospital Universitario Doctor José Molina Orosa

Arrecife, Lanzarote-Canary Islands, Spain

Hospital Galdakao-Usansolo Ospitalea

Galdakao, Vizcaya, Spain

Hospital Universitario de Albacete

Albacete, Spain

Hospital Germans Trias i Pujol

Badalona, Spain

Hospital Universitario de Bellvitge

Barcelona, Spain

Hospital Universitario Valle de Hebron

Barcelona, Spain

Hospital Universitario de Jaen

Jaén, Spain

Hospital Arnau de Vilanova

Lleida, Spain

Hospital Universitario de Fuenlabrada

Madrid, Spain

Hospital Universitario La Paz

Madrid, Spain

Hospital Universitario Ramon y Cajal

Madrid, Spain

Hospital Univeritario Puerta de Hierro

Madrid, Spain

Hospital Universitario de la Princesa

Madrid, Spain

Hospital Universitario Gregorio Marañon

Madrid, Spain

Hospital Universitario Infanta Leonor

Madrid, Spain

Hospital Universitario Rey Juan Carlos

Madrid, Spain

Hospital Regional Universitario de Málaga

Málaga, Spain

Hospital Universitario Joan XXIII

Tarragona, Spain

Hospital Universitario de Toledo

Toledo, Spain

Hospital Clínico Universitario de Valencia

Valencia, Spain

Hospital Universitario Rio Hortega

Valladolid, Spain

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07000526

Related Trials

Neonatal Neurological Observation With Video AI

NCT076288292 locations

Bispectral Monitoring on Mechanically Ventilated Patients

NCT072190691 location

Efficacy and Safety of Remimazolam Besylate for Sedation in Post-Non-Cardiac Surgery Patients Requiring Mechanical Ventilation

NCT065755301 location

Light and Anesthesia

NCT075174841 location

Effect of Remimazolam Sedation on Outcomes of Mechanically Ventilated Patients in the ICU

NCT075965891 location