JAK Signaling in Depression

This study is examining whether a JAK inhibitor (a type of anti-inflammatory drug) can help treat depression that is linked to inflammation in the body. Researchers believe that high levels of inflammation may contribute to depression that doesn't respond well to standard antidepressants. **You may be eligible if...** - You are between 25 and 55 years old - You have a current diagnosis of major depression or bipolar disorder (depressed phase) - Your depression score is above a moderate threshold (PHQ-9 > 14 at screening; HAM-D ≥ 18) - You have elevated inflammation markers (CRP ≥ 3 mg/L) - You have been off all antidepressants or psychiatric medications for at least 4 weeks (8 weeks for fluoxetine) - You have significant loss of interest or pleasure (anhedonia) **You may NOT be eligible if...** - You have an autoimmune disease, hepatitis B or C, or HIV - You have a history of cancer (other than minor surgery) - You have heart disease, stroke, blood clots, or other serious cardiovascular conditions - You have had major surgery recently or are scheduled for one - You have a history of a rare brain infection (progressive multifocal leukoencephalopathy) Talk to your doctor to see if this trial is right for you.