Renal Pelvic Denervation Pilot Trial

This pilot study is testing a new procedure called renal pelvic denervation — which uses energy to disrupt nerve signals from inside the kidney — as a way to lower blood pressure in people whose hypertension is not well controlled on medication. **You may be eligible if...** - You are currently taking 2 blood pressure medications (one should be an ACE inhibitor, ARB, or renin inhibitor; the other a calcium channel blocker or diuretic) - Your blood pressure medications have been stable for at least 30 days - Your daytime blood pressure readings are in a specific elevated range (systolic 135–170 mmHg, diastolic under 105 mmHg) - Your office blood pressure is between 140 and 180 mmHg systolic **You may NOT be eligible if...** - You have a history of atrial fibrillation (an irregular heartbeat) - You are pregnant, breastfeeding, or planning to become pregnant - Your blood pressure is extremely high (≥ 180/110 mmHg) - You have an untreated urinary tract infection - You have kidney structural problems (such as kidney stones, hydronephrosis, or duplicated collecting system) - You are on dialysis or have had a kidney transplant - You have only one functioning kidney Talk to your doctor to see if this trial is right for you.