A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension

This study is testing a new medication called RTN-001 to see if it can lower blood pressure in people whose high blood pressure is not well controlled even when taking two or more blood pressure medications. The drug is taken as a modified-release pill and may work through a different pathway than existing medications. **You may be eligible if...** - You are between 18 and 70 years old - You have high blood pressure that remains uncontrolled (130/80 mmHg or above) despite taking at least 2 blood pressure medications - You have been on the same blood pressure medications and doses for at least 30 days - You are not pregnant or breastfeeding **You may NOT be eligible if...** - Your blood pressure is extremely high (over 170 systolic or 110 diastolic) - You have a history of fainting, severe low blood pressure, or blackouts - You have secondary hypertension (blood pressure caused by another condition like a hormone problem) - You have heart disease, kidney disease (low kidney function), or active liver disease - You have had a heart attack, stroke, or major heart procedure within the past 3 months - You regularly use nitrates, alpha-blockers, SGLT2 inhibitors, or GLP-1 agonists - You use PDE5 inhibitors (e.g., Viagra) and cannot stop during the study Talk to your doctor to see if this trial is right for you.