PHOX2B PC-CAR T Cells for Relapsed Neuroblastoma

This study is testing a new type of CAR-T cell therapy called PHOX2B PC-CAR T cells for children and adults with high-risk neuroblastoma (a childhood cancer that starts in nerve tissue) that has come back or stopped responding to treatment. The therapy targets a protein called PHOX2B found on neuroblastoma cells. **You may be eligible if...** - You are 1 year of age or older - You have high-risk neuroblastoma that has relapsed, is refractory (not responding to treatment), or is persistent - Your cancer has been confirmed by prior biopsy - You carry specific HLA-A alleles (a genetic marker that allows the therapy to work) - You have measurable or detectable disease on imaging **You may NOT be eligible if...** - You do not have the required HLA-A genetic markers - Your neuroblastoma is not classified as high-risk - You are in first remission with no signs of relapse Talk to your doctor to see if this trial is right for you.