Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children
KBC Split
100 participants
Jun 2, 2025
OBSERVATIONAL
Conditions
Summary
Diagnosing acute appendicitis in children remains a clinical challenge, with delayed or incorrect diagnosis potentially leading to serious complications or unnecessary surgery. Prostaglandin E urinary metabolites (PGE-M) have been found elevated in various inflammatory conditions, but their diagnostic value in pediatric appendicitis is not well established. This study aims to assess the potential of PGE-M as a biomarker for acute appendicitis in children. The study will be conducted over 12 months and will include 100 children aged 5 to 17 years presenting with acute abdominal pain. In addition to routine laboratory tests, urinary PGE-M levels will be analyzed. The study involves minimal risk to participants
Eligibility
Plain Language Summary
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Interventions
Blood specimen collection for analysis of C-reactive protein, white blood cell count and neutrophile count.
Urine sample collection for analysis of creatinine and prostaglandin E urinary metabolites
Locations(1)
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NCT07008092