RecruitingNot ApplicableNCT07018986

The MIND-BC Study: MIND Diet for Breast Cancer Cognition

Sponsor

H. Lee Moffitt Cancer Center and Research Institute

Enrollment

200 participants

Start Date

Jul 9, 2025

Study Type

INTERVENTIONAL

Conditions

Breast Cancer

Summary

This fully, powered efficacy RCT, the MIND diet for Breast Cancer Cognition (MIND-BC), will evaluate the MIND diet in a rigorous, highly controlled academic cancer center. We will recruit breast cancer survivors reporting CRCI with a MIND diet score \< 8, based on a previously devised 14-item diet questionnaire designed to detect inadequate diet with respect to brain health (scores range from 0 to 14, with lower scores indicating a less adequate diet).14 Breast cancer survivors will have recently completed adjuvant treatment (i.e., 6 months to three years previously), to ensure that perceived cognitive impairment is likely chronic and due to cancer. To achieve maximal effect, the study consists of two 12-week phases 1) intervention phase, 2) maintenance phase.

Eligibility

Sex: FEMALEMin Age: 18 Years

Inclusion Criteria10

Previously diagnosed with stage I-III breast cancer.
Able to speak and read English.
Able to consume foods orally.
\>18 years of age.
Able to provide informed consent.
Have no documented or observable psychiatric or neurological disorder that would interfere with study participation (e.g., schizophrenia).
Report 'somewhat' to 'very much' cognitive impairment in the past week (i.e., a score ≥ 2 on a 0-4 scale) that they attribute to cancer or its treatment.
Report a MIND diet score \< 10 (range 0 to 14, higher score equates to higher diet quality).
Willing to consume the MIND diet.
Completed adjuvant treatment 6 months to three years previously.

Interventions

OTHERMIND Diet

a combination of the Mediterranean and DASH diets emphasizing consumption of high-nutrient, plant-based foods such as green leafy vegetables, nuts, berries, fish, and olive oil while limiting intake of foods high in saturated fat, pre-processed snacks, sugar, red and processed meat.

OTHERUsual Diet

Check-in sessions for the usual diet arm will focus on general health (e.g., healthy hair, skin, eyesight). None of the topics will include dietary information for the usual diet arm.