RecruitingNCT07019493

Young Stroke Service Deep Phenotyping: Exploring Recovery in Young Adult Survivors of Stroke

Sponsor

The Florey Institute of Neuroscience and Mental Health

Enrollment

100 participants

Start Date

Jul 19, 2025

Study Type

OBSERVATIONAL

Conditions

Stroke Stroke Patients

Summary

The Investigators are running a small, early-phase research study across several hospitals in Melbourne, Australia. The study will involve up to 100 young adults between the ages of 18 and 55 who have had a stroke. The goal is to test how practical it is to carry out a detailed health assessment process-called "deep phenotyping"-with this group. This process involves collecting a wide range of information and samples from stroke survivors to better understand each participant's condition. The Investigators will look at how well this approach works in practice, including how easy it is to use, whether it's done consistently, and how acceptable it is to participants. At the same time, the Investigators will also explore how different factors-such as biological markers (biomarkers), age, sex, type of stroke, lifestyle, and environment-might be related to stroke recovery. This pilot study will prepare for larger studies in the future.

Eligibility

Min Age: 18 YearsMax Age: 55 Years

Inclusion Criteria2

Between 18 and 55 years.
Within one month of acute stroke confirmed with standard of care brain imaging or clinical diagnosis or for those for whom recruitment <1 month of stroke is not possible they may be recruited to participate within 3-months of stroke

Exclusion Criteria4

Severe, intercurrent or progressive illness likely to EITHER
Have a prognosis for survival under 24 months; OR
In the opinion of the investigator will mask the importance to the individual participant data (e.g. severe MS, dementia, etc)
Major psychiatric condition requiring medical intervention

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Interventions

OTHERObservational Cohort

The deep phenotyping observational study observes young adult stroke recovery trajectories and will also explore potential recovery biomarkers via: advanced MRI imaging; samples including blood, saliva, urine and hair stored for future analysis that may include (but is not limited to) proteomics, genomics and cortisol; and, a PET scan sub study involving \~20 participants (additional inclusion criteria) exploring the association of reactive astrogliosis with recovery outcomes using the experimental Positron Emission Tomography 18F-SMBT-1 tracer (AU TGA CTN in place). Associations with personal and environmental factors including: physical activity and sleep quality via device (Actigraph and Somfit) and self-report; exposures such as home and work environments, diet, socioeconomic status, and dental health; quality of life, resilience, and locus of control. Monitor healthcare utilisation, changes in medication and medical condition, participant experience and response to the assessments.