Efficacy and Safety Assessment of Temporal Interference Stimulation to Improve Bipolar Depression

This study is testing a brain stimulation technique called temporal interference stimulation (a non-invasive type of electrical brain stimulation using electrodes placed on the scalp) to see if it can reduce depression in people with bipolar disorder. **You may be eligible if...** - You are right-handed and have completed at least 9 years of education - You have been diagnosed with bipolar depression (DSM-5 criteria) - Your depression is moderate-to-severe (HAMD-17 score of 18 or more) - Your manic symptoms are low (YMRS score 8 or less) - You have either not been on psychiatric medication, or are willing to undergo a 2-week medication washout before the study **You may NOT be eligible if...** - You have metal implants or other contraindications to MRI scanning - You have a history of seizures or certain neurological conditions - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.