Concomitant Radiotherapy and New Drugs in Metastatic Breast Cancer

This study is looking at how radiation therapy works alongside various modern systemic cancer treatments (such as targeted therapies, immunotherapy, or antibody-drug conjugates) in patients with stage IV (metastatic) breast cancer, to better understand safety and effectiveness when the two are combined. **You may be eligible if...** - You have stage IV (metastatic) breast cancer - You are currently receiving a systemic treatment such as targeted therapy, immunotherapy, an antibody-drug conjugate, or a tyrosine kinase inhibitor - You are a candidate for radiation therapy (for symptom relief or local control) **You may NOT be eligible if...** - The area being considered for radiation has been previously irradiated - You have an absolute medical contraindication to radiation - Your systemic treatment is part of a separate clinical trial Talk to your doctor to see if this trial is right for you.