Predictive Risk Factors for Pancreatic Fistula After Pancreaticoduodenectomy

This study is identifying factors that predict whether a patient will develop a serious complication called pancreatic fistula (a leak from the pancreas) after a major surgical procedure called a Whipple operation (pancreaticoduodenectomy), which removes part of the pancreas, small intestine, and bile duct. **You may be eligible if...** - You are over 18 years old - You have a resectable cancer of the lower bile duct, duodenum, the area around the bile duct opening (periampullary), or the head of the pancreas - Your cancer shows no signs of spread (no metastases, no major blood vessel involvement) - Your overall health is rated ASA class I or II (good to average surgical risk) **You may NOT be eligible if...** - You are not fit for surgery due to severe illness - Your cancer has spread to the liver, other organs, or distant lymph nodes - You are unable to consent to the study Talk to your doctor to see if this trial is right for you.