RecruitingNCT07022041

Sepsis and Hospital Mortality

Sepsis Mortality in Hospitals: a Quality Indicator in Acute Care Settings

Sponsor

University of Calabria

Enrollment

100 participants

Start Date

Jul 15, 2025

Study Type

OBSERVATIONAL

Conditions

Sepsis

Summary

Sepsis is one of the leading causes of hospital mortality, with a rate of approximately 20% (World Health Organization) among vulnerable patients admitted to high-intensity care units such as CCUs and inpatient wards. Currently, diagnostic criteria such as the Systemic Inflammatory Response Syndrome (SIRS) and the Sequential Organ Failure Assessment (SOFA) score, although widely used, lack sufficient specificity and accuracy. No established parameters are available for early and timely diagnosis. This study aims to address this gap by investigating the variability of blood plasma conductivity and dielectric constant using microwave probes previously validated for non-invasive glucose monitoring. The acquired data will be analyzed using the Anritsu VectorStar VNA to identify innovative and reliable parameters associated with the presence of severe infections.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

Age ≥ 18 years
Cardiology patients without documented infection (Control Group)
Patients with sepsis
Patients with nosocomial infection
Patients with myocarditis, endocarditis, or pericarditis
Ability to provide written informed consent

Exclusion Criteria6

Patients with severe or chronic medical conditions that may interfere with study results, such as autoimmune diseases, renal or hepatic failure
Patients taking medications that could affect the measured biophysical parameters, such as corticosteroids or immunosuppressants
Patients with cancer
Patients with diseases involving the immune system (e.g., lymphomas, leukemias)
Patients with congenital or acquired immunodeficiencies (e.g., HIV)
Patients who are unable to read and sign the informed consent form

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Interventions

DIAGNOSTIC_TESTconductivity and dieletric constant

collecting blood samples and directly measuring plasma conductivity and dielectric constant using microwave probes already validated for non-invasive glucose monitoring.