Phase II Trial Comparison of 3 vs 4 Fractions (BRACHY-FIT).
Brachytherapy Fractionation Individualized by Treatment Feasibility in Cervical Cancer: Phase II Trial Comparison of 3 vs 4 Fractions (BRACHY-FIT).
Stanford University
41 participants
Jun 3, 2025
INTERVENTIONAL
Conditions
Summary
This is a prospective non-randomized clinical trial to evaluate the feasibility of 3 fraction versus a standard 4 fraction high dose rate brachytherapy regimen in patients with locally advanced cervical cancer.
Eligibility
Inclusion Criteria4
- Histologically documented malignancy of the cervix and planned to receive brachytherapy as part of definitive treatment.
- ECOG performance status of 0-2
- Age ≥ 18 years old.
- Ability to understand and the willingness to provide written informed consent.
Exclusion Criteria5
- Contraindication to receiving radiotherapy as determined by treating radiation oncologist.
- Contraindication to receiving MRI.
- Prior radiation to the pelvis \> 3 months ago
- Age \< 18 years old.
- Pregnant or breast-feeding
Interventions
8 Gy per fraction for 3 fractions (total 24 Gy) for patients with locally advanced cervical cancer, based on individualized planning.
7 Gy per fraction for 4 fractions (total 28 Gy) as the standard-of-care brachytherapy regimen.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07022470