Perceptual Evaluation and Rehabilitation System Development for Congenital Hearing Loss
Development and Application of A Multimodal Perceptual Evaluation and Precision Rehabilitation System in Congenital Deafness
Eye & ENT Hospital of Fudan University
210 participants
Jul 4, 2025
INTERVENTIONAL
Conditions
Summary
This study aims to establish a novel multimodal evaluation and precision rehabilitation system for patients with congenital hearing loss who have received hearing aids, cochlear implantation, or emerging gene therapy. The proposed system will integrate age-stratified difficulty levels, combined with a gamified interaction platform or software designed to assess and train three core perceptual domains: auditory speech perception, music perception, and spatial hearing capabilities.
Eligibility
Inclusion Criteria5
- For Congenital Deafness Group: Patients with congenital hearing loss with hearing thresholds ≥65 dB who have received hearing aids, cochlear implantation, or gene therapy; Age between 1 and 35 years old, regardless of gender.
- For Healthy Controls Group: Participants with normal hearing thresholds (≤20 dB) whose age and gender matched to the patient group.
- Mandarin Chinese as the native language. Participants and/or their guardians must provide informed consent before the trial, voluntarily sign a written consent form, and commit to receive evaluation at specified time points.
- Capable of effective communication with researchers under the guardian's assistance and willing to cooperate and comply with the researchers' requirements.
- Participants and/or their guardians should have a correct understanding of the trial and appropriate expectations regarding potential benefits.
Exclusion Criteria5
- Presence of other otological disorders that may interfere with the surgical outcome or interpretation of study endpoints, such as otitis media, Meniere's disease, etc.
- Presence of other severe congenital diseases, such as congenital heart disease. Presence of severe systemic diseases or in the acute onset of diseases, such as pulmonary tuberculosis, active hepatitis B or C infection, active herpes zoster infection, pancreatitis, renal insufficiency, etc.
- Individuals with low immunity, a history of immune deficiency or organ transplantation.
- Individuals with a history of neurological, mental disorders, or moderate-to-severe cognitive dysfunction, such as epilepsy, dementia, autism spectrum disorders, etc.
- Any other conditions for which the investigators consider the subject unsuitable for participation in this clinical study.
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Interventions
This study constructed a novel multimodal assessment system to evaluate speech perception, music perception, and spatial hearing in congenital deafness patients , and subsequently generated targeted rehabilitation training plan based on the assessment data.
Locations(1)
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NCT07024524