RecruitingNCT07025070

The Link Between Physical Activity and Brain Health in Healthy Adults

The Link Between Strength and Endurance Training and Brain Health in Healthy Adults: A Comparative Study of Former Professional Athletes and Sedentary Individuals

Sponsor

Technical University of Madrid

Enrollment

60 participants

Start Date

Nov 25, 2024

Study Type

OBSERVATIONAL

Conditions

Alzheimer Disease Inactivity Preventive Therapy

Summary

The goal of this observational study is to investigate the cross-sectional relationship between physical activity and brain health from a multiscale approach (neuropsychology, neuroimaging, peripheral biomarkers and genetics) in former athletes and sedentary individuals. The main question it aims to answer is: Do former athletes have better brain structure than sedentary people? Evaluating the differences in neurodegenerative processes between competitive training and sedentary and inactivity.

Eligibility

Min Age: 40 YearsMax Age: 75 Years

Inclusion Criteria4

Group A: ex-athletes and continue to perform regular physical exercise (minimum 3 days/week of moderate-vigorous intensity).
Group B: sedentary individuals, (i.e., perform \<150 min of moderate intensity exercise per week or IPAQ score\<600 MET min/week).
In both groups (A and B) the conditions of physical exercise or sedentary lifestyle must have been maintained for at least 6 months prior to the evaluations.
Not having a history of neurological or psychiatric disorder or suffering from a serious medical condition

Exclusion Criteria11

Medical conditions that have a high risk of associated cognitive symptoms.
Severe head injury with loss of consciousness within the previous 5 years.
Alcoholism (\>3 alcoholic drinks per day).
Chronic use of anxiolytics, neuroleptics, narcotics, anticonvulsants, or sedative hypnotics.
Hearing or visual impairment that would preclude testing
History of neurological disease with clinically relevant impact on cognition (e.g. cerebrovascular disease).
Incidental structural brain findings with impact on cognitive impairment or survival (e.g., malignant brain tumor).
Presence of severe systemic disease (e.g., cancer under treatment).
Consumption of anabolic substances.
Problems understanding spoken or written Spanish.
Those with pacemakers or metallic implants that may interfere with the MRI.