RecruitingPhase 1NCT07025564

MiRisten for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

A Phase 1 Trial of miRisten in Adult Patients With Relapsed/Refractory AML


Sponsor

City of Hope Medical Center

Enrollment

12 participants

Start Date

Oct 24, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This phase I trial tests the safety, side effects, and best dose of miRisten in treating patients with acute myeloid leukemia (AML) that has come back after a period of improvement (relapsed) or that has not responded to previous treatment (refractory). MiRisten may stop the growth of cancer cells by blocking some of the molecules needed for cell growth. Giving miRisten may be safe, tolerable and/or effective in treating patients with relapsed or refractory AML.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug called MiRisten in people with acute myeloid leukemia (AML) — a fast-growing blood cancer — that has come back or stopped responding to previous treatments. **You may be eligible if...** - You are 18 or older - You have been diagnosed with AML that has relapsed (come back) or is refractory (not responding to treatment) - You have already tried or are ineligible for available AML therapies - You are in reasonably good health (ECOG 0–2) with a life expectancy of at least 3 months - Your liver function and blood counts meet minimum required levels - Tumor tissue from your diagnosis is available (or an exception is granted) **You may NOT be eligible if...** - Your AML has spread outside the bone marrow but not back to the marrow itself - You have not yet recovered from side effects of previous treatments - You have severely impaired liver function Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREBiospecimen Collection

Undergo bone marrow and blood sample collection

PROCEDUREEchocardiography Test

Undergo ECHO

DRUGmiR-126 Inhibitor miRisten

Given IV


Locations(1)

City of Hope Medical Center

Duarte, California, United States

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NCT07025564


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