RecruitingPhase 4NCT07028125

Digital Monitoring of Self-reported Symptoms by Patients Treated With Cabozantinib Plus Nivolumab for Advanced Clear-cell Renal Carcinoma

Digital Monitoring of Self-reported Symptoms by Patients Treated With Cabozantinib Plus Nivolumab for Advanced Clear-cell Renal Carcinoma: The CANIQOL Multicentre Study


Sponsor

Centre Francois Baclesse

Enrollment

83 participants

Start Date

Oct 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of the study is to evaluate the impact of digital monitoring of self-reported symptoms (PROs) on the adjustment of treatment management in patients treated with cabozantinib plus nivolumab for advanced clear cell renal cell carcinoma (RCC) in real life during the first 3 months of combined treatment


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is asking patients being treated with cabozantinib and nivolumab (a combination of targeted therapy and immunotherapy) for advanced kidney cancer to track their own symptoms digitally, to see if this improves their care. **You may be eligible if:** - You are over 18 years old - You have advanced or metastatic clear-cell kidney cancer - You have not had prior systemic treatment for your kidney cancer - Your doctor has already decided to treat you with cabozantinib plus nivolumab as your first treatment **You may NOT be eligible if:** - You are pregnant or planning to become pregnant during treatment - You are breastfeeding - You are not willing to use effective contraception - You have already received systemic treatment for kidney cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGcabozantinib and nivolumab

cabozantinib and nivolumab according to the labelling indication, namely: * CABOZANTINIB 40 mg per oral route once daily * NIVOLUMAB 240 mg per intravenous route every 2 weeks During this combined treatment, the digital monitoring system is used to collect weekly data on treatment tolerance by patient self-report.


Locations(10)

Centre Hospitalier d'Annecy

Annecy, France

Institut Sainte Catherine

Avignon, France

Centre Hospitalier de Bayeux

Bayeux, France

Centre François Baclesse

Caen, France

Polyclinique du Parc Elsan

Caen, France

Ghpso Creil

Creil, France

Centre Hospitalier de Lorient

Lorient, France

GHR Mulhouse Sud Alsace

Mulhouse, France

CHU

Saint-Etienne, France

Centre Hospitalier de Tours

Tours, France

View Full Details on ClinicalTrials.gov

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NCT07028125


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