RecruitingPhase 2NCT07029009

Liraglutide Treatment in Patients With Maturity-onset Diabetes of the Young (MODY)

Investigating Enteroendocrine Dysfunction, Metabolism, and Response to Liraglutide in Patients With Maturity-onset Diabetes of the Young (MODY)

Sponsor

Mansa

Enrollment

50 participants

Start Date

May 8, 2025

Study Type

INTERVENTIONAL

Conditions

Maturity Onset Diabetes of the Young

Summary

The reason for this research study is to better understand the use of liraglutide, a commonly prescribed Type 2 diabetes medication, in patients with a diagnosis of maturity-onset diabetes of the young (MODY). The investigators are interested in better understanding the way that this drug affects the metabolism and hormone levels of a person with MODY. Many people with MODY report having gastrointestinal (GI) issues such as an upset stomach. Investigators also are interested in finding out if this drug will help with GI issues. If liraglutide does help with this symptom of MODY, the investigators want to know why this happens. If this drug is effective for participants, the investigators will use participants cells to make human induced pluripotent stem cell (iPSC). This means that the investigators will use participant cells to create what are called stem cells, which are cells in the body that are able to be told what their job is. Investigators will use these cells to see what happens in gastrointestinal (GI) tract.

Eligibility

Min Age: 10 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether liraglutide (a GLP-1 medication commonly used for type 2 diabetes and weight loss) can also help people with a rare genetic type of diabetes called MODY (Maturity-Onset Diabetes of the Young). **You may be eligible if:** - You have been diagnosed with MODY confirmed through genetic testing - Your HbA1c (average blood sugar level over 3 months) is above 6.5%, indicating blood sugar is not fully controlled **You may NOT be eligible if:** - You have had a severe allergic reaction to GLP-1 medications - You are already taking a GLP-1 medication - You are currently pregnant or plan to become pregnant - You have a personal or family history of medullary thyroid cancer or pancreatitis - You have active kidney disease - You have had severely low blood sugar (below 50 mg/dL) in the past 3 months - Your HbA1c is above 10% (very poorly controlled diabetes) Talk to your doctor to see if this trial is right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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