RecruitingNCT07029230

Blood Based Assessment of sST2, Taken During and After Surgery, for Pediatric Patients With Heart Defects to Predict Heart Failure.

Biomarker in Congenital Cardiac Surgery - sST2 Marker in Heart Failure in Congenital Heart Disease After Surgery Research and Translational Study


Sponsor

Martin Schweiger

Enrollment

225 participants

Start Date

Sep 10, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

Patients younger than 18 scheduled for congenital heart surgery will be assessed during and post-operatively as well as at the first follow-up after 9-12 month for the novel biomarker sST2. We will assess the marker independently and in evaluation with other blood biomarkers to evaluate sings of heart failure. Compared to established biomarkers, sST2 promises thereby to be less variable to factors like age or acute kidney injury, rendering it potentially more reliable in the field of congenital cardiac surgery.


Eligibility

Max Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is measuring a blood protein called sST2 in children who are having open-heart surgery to see if it can predict which patients might develop heart failure after surgery. **You may be eligible if:** - Your child is scheduled for open-heart surgery (cardiopulmonary bypass) for a heart condition - You and/or your child speak German well enough to provide written consent **You may NOT be eligible if:** - Your child has a known genetic condition that limits life expectancy - Your child has a syndrome that is likely to require surgery on more than one organ - Your child weighs less than 2.5 kg at the time of surgery - Your child is already enrolled in another interventional clinical study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

University Children's Hospital Zurirch

Zurich, Canton of Zurich, Switzerland

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NCT07029230


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