RecruitingNCT07029373
Plasma Calcitonin Gene-Related Peptide (CGRP) Levels in Patients With Head and Neck Malignancies Undergoing Radiotherapy
A Prospective Clinical Study for Analyzing Plasma Calcitonin Gene-Related Peptide (CGRP) Levels in Patients With Head and Neck Malignancies Undergoing Radiotherapy
Sponsor
West China Hospital
Enrollment
50 participants
Start Date
Jul 4, 2025
Study Type
OBSERVATIONAL
Conditions
Summary
This prospective study investigates the dynamic changes in plasma calcitonin gene-related peptide (CGRP) levels during radiotherapy and their association with radiotherapy-related pain in patients with head and neck malignancies.
Eligibility
Min Age: 18 Years
Inclusion Criteria6
- Age ≥ 18 years
- Histologically confirmed head and neck malignancy
- Planned to receive definitive or postoperative adjuvant radiotherapy
- Radiotherapy duration ≥ 4 weeks, with irradiation field involving the oral cavity, pharynx, or neck region
- Able and willing to provide written informed consent
- Able to complete pain assessments and blood sample collection
Exclusion Criteria6
- History of significant chronic pain prior to radiotherapy (e.g., postherpetic neuralgia, rheumatoid arthritis)
- Presence of uncontrolled hypertension, diabetes, or migraines
- Presence of other active malignancies or major systemic diseases (e.g., severe hepatic or renal dysfunction)
- Currently receiving or recently received treatments that may significantly affect pain perception (e.g., opioids, antidepressants)
- Pregnant or breastfeeding
- Inability to complete follow-up or poor treatment compliance
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07029373
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