RecruitingPhase 2NCT07033026

An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.

A Phase 2, Multicenter, Randomized, Double Blind, Placebo-controlled Study to Assess the Efficacy, Safety, and Tolerability of NGM120 in Participants With Colorectal Cancer Who Have Cancer Cachexia


Sponsor

NGM Biopharmaceuticals, Inc

Enrollment

136 participants

Start Date

Jun 25, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A multi-center evaluation of NGM120 in a randomized, double-blind, placebo-controlled study in participants with colorectal cancer who have cancer cachexia.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests a drug called NGM120 in people with colorectal cancer who are experiencing cachexia — a serious condition involving severe, unintentional weight loss and muscle wasting that often happens in advanced cancer. **You may be eligible if...** - You have active colorectal cancer - You have cachexia, defined by significant unintentional weight loss - You have signed the consent form **You may NOT be eligible if...** - Your decreased food intake has a reversible cause that is being treated - You are currently receiving tube feeding or IV nutrition - Your weight loss is caused by something other than cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNGM120 Q4W

NGM120 given subcutaneously every 4 weeks

DRUGNGM120 Q8W

NGM120 given subcutaneously every 8 weeks

DRUGPlacebo given

Placebo given subcutaneously every 4 weeks


Locations(28)

NGM Clinical Study Site

Los Angeles, California, United States

NGM Clinical Study Site

Los Angeles, California, United States

NGM Clinical Study Site

Santa Rosa, California, United States

NGM Clinical Study Site

Margate, Florida, United States

NGM Clinical Study Site

Baltimore, Maryland, United States

NGM Clinical Study Site

New York, New York, United States

NGM Clinical Study Site

Toledo, Ohio, United States

NGM Clinical Study Site

Youngstown, Ohio, United States

NGM Clinical Study Site

Dallas, Texas, United States

NGM Clinical Study Site

Kingwood, Texas, United States

NGM Clinical Study Site

Laredo, Texas, United States

NGM Clinical Study Site

Richmond, Virginia, United States

NGM Clinical Study Site

Appleton, Wisconsin, United States

NGM Clinical Study Site

Tbilisi, Georgia

NGM Clinical Study Site

Tbilisi, Georgia

NGM Clinical Study Site

Tbilisi, Georgia

NGM Clinical Study Site

Tbilisi, Georgia

NGM Clinical Study Site

Tbilisi, Georgia

NGM Clinical Study Site

Goyang, South Korea

NGM Clinical Study Site

Goyang, South Korea

NGM Clinical Study Site

Incheon, South Korea

NGM Clinical Study Site

Seoul, South Korea

NGM Clinical Study Site

Seoul, South Korea

NGM Clinical Study Site

Seoul, South Korea

NGM Clinical Study Site

Suwon, South Korea

NGM Clinical Study Site

Taichung, Taiwan

NGM Clinical Study Site

Taipei, Taiwan

NGM Clinical Study Site

Taoyuan, Taiwan

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07033026


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