CRC (Colorectal Cancer) Clinical Trials

20 recruitingLast updated: June 17, 2026

There are 20 actively recruiting crc (colorectal cancer) clinical trials across 24 countries. Studies span Phase 1, Phase 2, Early Phase 1, Not Applicable, Phase 3. Top locations include Fairfax, Virginia, United States, Houston, Texas, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


CRC (Colorectal Cancer) Trials at a Glance

20 actively recruiting trials for crc (colorectal cancer) are listed on ClinicalTrialsFinder across 6 cities in 24 countries. The largest study group is Phase 1 with 8 trials, with the heaviest enrollment activity in Fairfax, Houston, and New York. Lead sponsors running crc (colorectal cancer) studies include City of Hope Medical Center, Wondercel Biotech (ShenZhen), and Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis.

Browse crc (colorectal cancer) trials by phase

Treatments under study

About CRC (Colorectal Cancer) Clinical Trials

Looking for clinical trials for CRC (Colorectal Cancer)? There are currently 20 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new CRC (Colorectal Cancer) trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about CRC (Colorectal Cancer) clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 20 trials

Recruiting
Phase 1

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

CancerAdvanced Solid TumorsNSCLC (Non-small Cell Lung Cancer)+2 more
Alterome Therapeutics, Inc.448 enrolled12 locationsNCT06835569
Recruiting
Phase 1

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

Non-small Cell Lung CancerNSCLCMetastatic Pancreatic Ductal Adenocarcinoma+11 more
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)665 enrolled17 locationsNCT06917079
Recruiting
Phase 3

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

CRC (Colorectal Cancer)
Incyte Corporation700 enrolled274 locationsNCT07284849
Recruiting
Phase 1

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

Head and Neck CancerHNSCCColo-rectal Cancer+4 more
ALX Oncology Inc.170 enrolled8 locationsNCT07085091
Recruiting
Not Applicable

Feasibility of a Multi-Channel Intervention to Promote Colorectal Cancer Screening Among American Indians in Oklahoma

CRC (Colorectal Cancer)CRC Screening
University of Oklahoma150 enrolled1 locationNCT07254910
Recruiting
Not Applicable

A Prospective Study to Evaluate the Performance of a Real-time System in the Estimation of Colorectal Polyp Size

Artificial Intelligence (AI)CRC (Colorectal Cancer)Colonic Polyps
Chinese University of Hong Kong278 enrolled1 locationNCT06957015
Recruiting
Phase 1

A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

Solid Tumor MalignanciesCRC (Colorectal Cancer)KRAS G12C Mutation+1 more
Kumquat Biosciences Inc.140 enrolled11 locationsNCT06720987
Recruiting
Phase 2

An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.

Colorectal, CancerCancer CachexiaCRC (Colorectal Cancer)
NGM Biopharmaceuticals, Inc136 enrolled28 locationsNCT07033026
Recruiting
Phase 2

Neoadjuvant SHR-1701 Plus Chemoradiotherapy for Locally Advanced Rectal Cancer

CRC (Colorectal Cancer)
Hong Qiu48 enrolled1 locationNCT07478731
Recruiting

Validation of High-Throughput Large-Format Tissue Preprocessing for Lung and Colorectal Cancer

Lung Cancer (Diagnosis)CRC (Colorectal Cancer)
Nanfang Hospital, Southern Medical University1,000 enrolled1 locationNCT07239063
Recruiting
Phase 1

A Phase 1 Study of TGI-5 as Monotherapy and in Combination With Nivolumab in Subjects With Locally Advanced/Metastatic Solid Tumors

Melanoma (Skin Cancer)NSCLC (Non-small Cell Lung Cancer)CRC (Colorectal Cancer)+1 more
Hefei TG ImmunoPharma Co., Ltd.194 enrolled1 locationNCT07376707
Recruiting
Early Phase 1

Universal CAR-T Cells (REVO-UWD-01) for Metastatic Colorectal Cancer

Metastatic Colorectal CancerCRC (Colorectal Cancer)
Wondercel Biotech (ShenZhen)30 enrolled2 locationsNCT06653010
Recruiting
Phase 1

A Prospective, Safety, and Efficacy Clinical Trial of Pressurized Intraperitoneal Aerosol Therapy for Peritoneal Metastasis of Colorectal Cancer

CRC (Colorectal Cancer)Peritoneal Metastasis
Second Affiliated Hospital, School of Medicine, Zhejiang University42 enrolled1 locationNCT07349043
Recruiting

Identification of New Non-invasive, Predictive, and Diagnostic Biomarkers for Colorectal Cancer

CRC (Colorectal Cancer)Adenoma Colon
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis60 enrolled1 locationNCT07153458
Recruiting
Phase 1

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

Endometrial CancerMetastatic Solid TumorSolid Tumor, Adult+4 more
Sairopa B.V.130 enrolled7 locationsNCT05856981
Recruiting
Phase 1Phase 2

A Study of GFH375 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors Harboring KRAS G12D Mutation

Advanced Solid Tumors CancerPDACCRC (Colorectal Cancer)
Genfleet Therapeutics (Shanghai) Inc.126 enrolled4 locationsNCT07259590
Recruiting

Development of a cfDNA 5mC/5hmC-based Biomarker Panel to Predict Targeted Therapy Efficacy in mCRC

CRC (Colorectal Cancer)
City of Hope Medical Center500 enrolled1 locationNCT07224841
Recruiting

cfDNA 5mC/5hmC Biomarkers to Predict Chemotherapy Response in Metastatic Colorectal Cancer

CRC (Colorectal Cancer)
City of Hope Medical Center600 enrolled1 locationNCT07224815
Recruiting

An Exploratory Study on Gene Methylation Detection of Colorectal Cancer

CRC (Colorectal Cancer)Adenoma Colon
Zhejiang Provincial People's Hospital450 enrolled1 locationNCT07033156
Recruiting
Early Phase 1

Autologous CAR-T Cells (WD-01) for Metastatic Colorectal Cancer

Metastatic Colorectal CancerCRC (Colorectal Cancer)
Wondercel Biotech (ShenZhen)30 enrolled2 locationsNCT06675513