RecruitingNCT07033156

An Exploratory Study on Gene Methylation Detection of Colorectal Cancer

An Exploratory Study on Gene Methylation Detection of Colorectal Cancer（CRC）

Sponsor

Zhejiang Provincial People's Hospital

Enrollment

450 participants

Start Date

Dec 24, 2024

Study Type

OBSERVATIONAL

Conditions

CRC (Colorectal Cancer)Adenoma Colon

Summary

The goal of this exploration study is to evaluate the performance of a colorectal cancer (CRC) early screening model based on the DNA methylation technology platform. The study focuses on individuals over the age of 40 and aims to identify and verify methylation biomarkers for colorectal cancer using stool samples . The main question it aims to answer is: Can a DNA methylation-based model effectively detect colorectal cancer and adenoma in individuals over 40 using non-invasive stool samples? Participants will provide stool samples for methylation analysis. The study results will be used solely for internal product performance evaluation and optimization by the sponsor and will not be used for product registration or influence any clinical diagnosis.

Eligibility

Min Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates whether a stool (poop) or blood test that looks for abnormal gene methylation — chemical changes to DNA — can detect colorectal cancer (bowel cancer) more accurately. **You may be eligible if...** - You are 40 years old or older - You are having (or scheduled to have) a colonoscopy - Your medical information (age, diagnosis, test results) can be traced and confirmed - Your stool and blood samples can be collected within 3 months before your colonoscopy **You may NOT be eligible if...** - Your sample collection information is incomplete or unclear - You are under 40 years old Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIAGNOSTIC_TESTThis study does not require intervention trials

This study does not require intervention trials

Locations(1)

Zhejiang Provincial People's Hospital

Hangzhou, Zhejiang, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07033156

Related Trials

Feasibility of a Multi-Channel Intervention to Promote Colorectal Cancer Screening Among American Indians in Oklahoma

NCT072549101 location

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

NCT070850917 locations

A Prospective Study to Evaluate the Performance of a Real-time System in the Estimation of Colorectal Polyp Size

NCT069570151 location

A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

NCT0672098711 locations

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

NCT07284849272 locations