RecruitingEarly Phase 1NCT07033845

Pharmacokinetic Study of Topical Phenylephrine


Sponsor

Applied Biology, Inc.

Enrollment

24 participants

Start Date

Jun 30, 2025

Study Type

INTERVENTIONAL

Summary

Pharmacokinetic Study of Topical Phenylephrine


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 55 Years

Inclusion Criteria5

  • Healthy females, age 18-55
  • BMI: 18-30 kg/m²
  • Fitzpatrick Skin Types I-IV (to standardize absorption risk)
  • Scalp free from irritation, dermatologic disease, or damage
  • Able to refrain from using other topical scalp products

Exclusion Criteria5

  • History of cardiovascular disease, hypertension, or arrhythmia
  • Scalp infections, wounds, or significant hair loss
  • Recent use of medications that interfere with CYP enzymes or adrenergic systems
  • Known sensitivity to phenylephrine or ethanol
  • Positive drug screen or abnormal ECG at screening

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Interventions

DEVICEPhenylephrine

Topical Phenylephrine


Locations(1)

University of Rome ("G. Marconi")

Rome, Italy

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NCT07033845