RecruitingNCT07037082

Understanding Cycles to Improve Women's Health

Understanding Socio-ecological Variation in Menstrual Cycles to Advance Female Health

Sponsor

University Hospital, Montpellier

Enrollment

320 participants

Start Date

Sep 1, 2025

Study Type

OBSERVATIONAL

Conditions

Socioeconomic Factors Woman of Reproductive Age

Summary

Introduction: The C-HEALTH study investigates how environmental and socio-economic conditions affect women's menstrual cycles and reproductive health. Aim: To compare progesterone levels during the luteal phase among women from different socio-economic backgrounds living in rural and urban areas in southern France. Methods: This is a prospective observational study involving 320 healthy women of reproductive age. * Hormones (progesterone, estradiol) will be measured daily in saliva. * Inflammation (Protéine C Réactive: CRP) will be measured five times per cycle via blood drops. * Participants will wear a smart ring to monitor body temperature and activity. * Daily symptoms and lifestyle data will be collected. * Environmental exposures (pollution, stress, living conditions) will be assessed and linked to menstrual health outcomes.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 39 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Ovulation test, Self-collection of dried blood spots, and others for people with socioeconomic factors and woman of reproductive age. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

OTHERSelf-saliva sampling

Self-saliva samples are taken every day from D1 inclusive over 1 consecutive cycle, to measure progesterone (P4) and estradiol (E2) concentrations.

OTHERSelf-collection of dried blood spots

Self-blood sampling is done 5 times during the cycle to measure protéine C-Réactive (CRP) concentrations.

OTHERWearing the connected ring

A connected ring is worn every day of the observed cycle, while maintaining lifestyle habits, to measure daily body temperature, assess heart rate variability and resting heart rate, evaluate physical activity and energy expenditure, assess stress level, and evaluate sleep quality.

OTHEROvulation test

An ovulation test (Ovulatest®) is carried out from day 7 until a test is positive, or until day 39 if ovulation is not detected