RecruitingNot ApplicableNCT07037511

Effects of Salbutamol in Athletes and Implications for Screening and Sports

Physiological, Sensory and Ergogenic Effects of Salbutamol - Implications for Athletic Screening and β2 Agonist Use in Sport

Sponsor

University of British Columbia

Enrollment

64 participants

Start Date

Oct 30, 2025

Study Type

INTERVENTIONAL

Conditions

Asthma Healthy Effect of Drug

Summary

β2-Agonists, commonly used to treat asthma, have also been used by athletes to enhance performance, leading to their ban by the International Olympic Committee in 1972. Research has shown non-asthmatics receive no benefit from these drugs at therapeutic dosages; however, many elite athletes still use them, and asthmatic athletes often win more Olympic medals. In some non-asthmatics, β2-agonists may improve breathing limitations during high intensity exercise, which may improve performance. Therefore, we aim to examine if there is a select group of non-asthmatic individuals who experience breathing limitations that may receive benefit from β2-agonists.

Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study examines how salbutamol (a common asthma inhaler medication, also known as albuterol) affects athletic performance and breathing in elite endurance athletes, and what this means for anti-doping screening in sports. **You may be eligible if...** - You are a high-level endurance athlete (runner or cyclist) who is currently training or competing - Your aerobic fitness (VO2max) is above 120% of the predicted level - Your BMI is between 18 and 30 - You can read and understand English **You may NOT be eligible if...** - You are a current or former smoker - You have asthma or other respiratory conditions - You are taking any medications that could affect lung function or the study results Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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