Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide

This pilot study is testing whether semaglutide — a medication commonly used for diabetes and weight loss — can help reduce heavy drinking in people living with HIV who also have an alcohol use disorder. This is an off-label use, meaning the drug isn't currently approved for this purpose, and the study aims to see if it's safe and effective in this specific group. **You may be eligible if...** - You have been diagnosed with HIV - You receive care at the Atlanta VA Healthcare System - You are 18 years of age or older - You have been diagnosed with mild, moderate, or severe alcohol use disorder - Blood tests show significant recent alcohol use - You are currently prescribed 5 or more medications - You have a cell phone or reliable contact number - You can provide written consent **You may NOT be eligible if...** - You have certain active health conditions that make the medication unsafe - You have a history of pancreatitis or specific thyroid cancers - You are pregnant or planning to become pregnant - You are already enrolled in another alcohol treatment study Talk to your doctor to see if this trial is right for you.