RecruitingPhase 1Phase 2NCT07042802

A Phase Ib/Ⅱ Clinical Trial of LBL-024 Combined With Paclitaxel in Patients With Platinum-resistant Ovarian Cancer

An Open-label, Multicenter Phase Ib/Ⅱ Study to Evaluate the Efficacy and Safety of LBL-024 in Combination With Paclitaxel Injection in Patients With Platinum-resistant Ovarian Cancer


Sponsor

Nanjing Leads Biolabs Co.,Ltd

Enrollment

110 participants

Start Date

Dec 2, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This trial is an open-label, multicenter phase Ib/II clinical study of LBL-024 combination therapy in patients with platinum-resistant ovarian cancer (OC),To evaluate the efficacy and safety of LBL-024 combination therapy in the treatment of advanced recurrent platinum-resistant ovarian cancer (OC) patients.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of an experimental drug (LBL-024, a type of immunotherapy) with paclitaxel (a standard chemotherapy) in women with platinum-resistant ovarian cancer — meaning their cancer stopped responding to platinum-based chemotherapy. The goal is to see if this combination can produce better results than chemotherapy alone. **You may be eligible if...** - You are 18 or older - You have been diagnosed with ovarian cancer that has stopped responding to platinum-based chemotherapy - Your cancer is measurable on imaging scans (based on standard RECIST criteria) - You are in reasonably good physical condition (ECOG 0–1) - Your expected survival is at least 12 weeks - Your blood counts and organ function meet the required levels **You may NOT be eligible if...** - Your cancer still responds to platinum-based chemotherapy - You have significant uncontrolled medical conditions - You have received too many prior lines of therapy - You are pregnant or breastfeeding - Your organ function does not meet the required levels Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGLBL-024 for Injection

LBL-024 Intravenous infusion.

DRUGPaclitaxel Injection

Paclitaxel Intravenous infusion.


Locations(13)

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Beijing, Beijing Municipality, China

Beijing Obstetrics and Gynecology Hospital Capital Medical University

Beijing, Beijing Municipality, China

Fujian Cancer Hospital

Fuzhou, Fujian, China

Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China

Harbin Medical University Cancer Hospital

Harbin, Heilongjiang, China

AnYang Tumor Hospital

Anyang, Henan, China

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, China

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China

The First Hospital of China Medical University

Shenyang, Liaoning, China

Shandong Cancer Hospital

Jinan, Shandong, China

Tianjin Medical University Cancer Institute &Hospital

Tianjin, Tianjin Municipality, China

Yunnan Cancer Hospital

Kunming, Yunnan, China

Zhejiang Cancer Hospital

Hangzhou, Zhejiang, China

View Full Details on ClinicalTrials.gov

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NCT07042802


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