RecruitingNot ApplicableNCT07044466

Social Functioning in Opioid Use Disorder

Real-world Assessment of Social Functioning During OUD Treatment: Integrating Reports From Patients and Their Concerned Significant Others

Sponsor

Medical University of South Carolina

Enrollment

230 participants

Start Date

Jul 31, 2026

Study Type

INTERVENTIONAL

Conditions

Opioid-use Disorder

Summary

Problems with social functioning are core to opioid use disorder (OUD), though specific, modifiable social functioning targets and how they relate to OUD treatment outcomes are poorly understood. This study will utilize both data from both patients with OUD and their concerned significant other (CSO) to examine associations between specific social functioning metrics and OUD treatment outcomes. Findings from this study will inform future precision-medicine approaches for people with OUD, a population in significant need of enhanced treatment approaches to combat opioid morbidity and mortality.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

Any sex or gender; any race or ethnicity; aged 18 years or older
Patient participants must meet DSM-5 diagnostic criteria for current (i.e., past 12 months) OUD (assessed via the Quick Structured Clinical Interview for DSM-5; Quick SCID)
Patient participants must be on buprenorphine, as prescribed by their provider, for no more than 4 weeks prior to study initiation
Patient participants must be in treatment at one of the following clinics in the Charleston area: MUSC's Center for Drug and Alcohol Programs (CDAP) clinic, MUSC's Bridge Clinic, the Charleston Center, Hope Integrative Medicine, or BHG Charleston
Concurrent substance use disorders (e.g., alcohol, cannabis) for the patient participant are acceptable, provided opioids are the patient participant's primary substance of choice
Patient participants must identify a CSO participant who consents to participation in the study as well

Exclusion Criteria7

Moderate-to-severe opioid withdrawal as defined by a score of ≥21 on the Subjective Opioid Withdrawal Scale
Meeting DSM-5 criteria for a history of or current psychotic or bipolar disorders
Current suicidal or homicidal ideation and intent; participants who present a serious suicide risk are likely to require hospitalization during the study and they will be referred clinically
CSO participants meeting DSM-5 criteria for opioid use disorder or any other substance use disorder, excepting tobacco use disorder
Severe interpersonal violence in the past six months between the patient and the CSO, as defined by an adapted version of the Conflict Tactics Scaled Revised (CTS-2)
Pregnancy for patient participants
Prisoners, institutional individuals, and children will not be recruited for this study.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

BEHAVIORALCBT4CBT-Buprenorphine

CBT4CBT-Buprenorphine is an evidence-based, Internet-delivered cognitive behavioral therapy program for individuals prescribed buprenorphine by a medical provider. It includes eight 30-minute modules.