Shortened Course of Radiation Therapy After Trans-oral Robotic Surgery in Patients With HPV-Mediated Oropharyngeal Squamous Cell Carcinoma.

This study is testing whether a shorter course of radiation therapy (fewer sessions) works just as well as the standard longer course for people with HPV-related throat cancer (oropharyngeal cancer) who had robotic surgery to remove the tumor. Shorter radiation means fewer trips to the clinic and potentially fewer side effects. **You may be eligible if...** - You are 18 or older - You have been diagnosed with throat cancer (specifically oropharyngeal squamous cell carcinoma) linked to HPV - You had or are having robotic surgery through the mouth to remove the tumor - Your cancer is at an early to intermediate stage - You are a non-smoker or have not smoked in at least 1 month **You may NOT be eligible if...** - You have had previous head and neck radiation therapy - Your cancer has spread to distant parts of the body - You have had prior chemotherapy or cancer treatment recently - You have certain other active cancers Talk to your doctor to see if this trial is right for you.