RecruitingNot ApplicableNCT07044830

Obstructive Sleep Apnea Treatment From Acute to Chronic Phase of Stroke

Obstructive Sleep Apnea Treatment From Acute to Chronic Phase of Stroke - A Randomized Clinical Trial

Sponsor

Hospital das Clínicas de Ribeirão Preto

Enrollment

425 participants

Start Date

Feb 28, 2024

Study Type

INTERVENTIONAL

Conditions

Obstructive Sleep Apnea Ischemic Stroke

Summary

The study aims to evaluate whether early treatment of obstructive sleep apnea with continuous positive airway pressure in ischemic stroke patients has a favorable effect on functional recovery.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria5

Supratentorial non-lacunar ischemic stroke, including anterior, middle, and posterior cerebral artery territories
Aged 18 to 80 years
Symptom onset or symptom recognition to admission < 12 hours
NIHSS score ≥ 4 and ≤ 20 at enrollment
Signed informed consent form obtained from the participant or their legal representative

Exclusion Criteria14

Prior stroke
Previous diagnosis of OSA with current CPAP use or previously failed CPAP
Pre-stroke disability (mRS > 1)
Coma or stupor
Orotracheal intubation
Clinical instability or severe pre-existing illness (e.g., heart failure, oxygen-dependent COPD, renal or hepatic failure)
Psychomotor agitation
High likelihood of neurosurgical intervention within the first 48 hours
Oxygen therapy >2 L/min
Known severe neurological disease (e.g., dementia, Parkinson's disease, multiple sclerosis, or other neurodegenerative conditions)
Chronic alcohol or drug use with high risk of withdrawal during hospitalization
Pregnant or suspected pregnant women
Inability to complete follow-up for any reason
Any contraindication to CPAP use