Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.
Effects of Fresh Mango as a Sugar Substitute Within High and Low Glycemic Breakfasts on Postprandial Glucose and Insulin
Ball State University
24 participants
Mar 26, 2025
INTERVENTIONAL
Conditions
Summary
Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to more favorable blood sugar, insulin, and vascular responses after eating breakfast meals. The investigators will compare the postprandial glycemic, insulinemic, and vascular response to low and high glycemic meals sweetened with either fresh mango or sucrose.
Eligibility
Inclusion Criteria14
- - 45 years.
- Body mass index between 18.5-35.0 kg/m2
- Not pregnant (females only)
- Not postmenopausal (females only).
- Not been diagnosed with cardiovascular disease.
- Not been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes)
- Not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
- Does not regularly take anti-inflammatory drugs (more than 2x week).
- Does not use glucose-lowering drugs (e.g., metformin)
- Does not use lipid-lowering drugs (e.g., statins)
- Does not use tobacco products or any illicit drugs.
- Does not have a pacemaker.
- Can consume mango, wheat, gluten, and milk.
- Can stay in a supine position in the dark for at least ten minutes.
Exclusion Criteria14
- Not between the ages of 18-45
- Body mass index < 18.5 kg/m2 or >35.0 kg/m2
- Pregnant (females only)
- Postmenopausal status (females only).
- Been diagnosed with cardiovascular disease.
- Been diagnosed with a cardiometabolic conditions (e.g., type 2 diabetes)
- Been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
- Regularly take anti-inflammatory drugs (more than 2x week).
- Uses glucose-lowering drugs (e.g., metformin)
- Uses lipid-lowering drugs (e.g., statins)
- Uses tobacco products or any illicit drugs.
- Have a pacemaker.
- Allergic to mango, wheat, gluten, and/or milk.
- Unable to lay in supine position in the dark for at least ten minutes.
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Interventions
Low-glycemic breakfast of 80 grams of oats prepared with 473mL water and sweetened with 146 grams of mango.
High-glycemic breakfast of 84 grams of corn flakes prepared with 355mL of 2% milk and sweetened with 262 grams of mango.
Low-glycemic breakfast of 80 grams of oats prepared with 473mL of water and sweetened with 20 grams of table sugar.
High-glycemic breakfast of 84 grams of corn flakes prepared with 355mL of 2% milk and sweetened with 36 grams of table sugar.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07045051