Evaluation of the Natera Colorectal Cancer Screening Test in an Average Risk Population (FIND-CRC)

This study is testing a new blood-based colorectal cancer screening test (looking for cancer DNA in the blood) in average-risk people who are already planning to get a routine colonoscopy. The goal is to see how well this blood test compares to colonoscopy findings for detecting polyps or cancer. **You may be eligible if...** - You are 40 years or older - You are planning to get a routine colonoscopy (not for symptoms — just routine screening) - You have not had a colonoscopy in the past 9 years - You are willing to give blood samples before your colonoscopy **You may NOT be eligible if...** - You have a personal history of any cancer (except for fully treated skin basal cell or squamous cell cancers) - You have had precancerous polyps on a previous colonoscopy - You are experiencing symptoms that prompted the colonoscopy - You have inflammatory bowel disease or a hereditary cancer syndrome (like Lynch Syndrome) - You have had prior colorectal surgery (other than for diverticular disease) Talk to your doctor to see if this trial is right for you.