RecruitingNot ApplicableNCT07049783

Examining the Circadian Timing Effects of the Hypotensive Response to Exercise


Sponsor

Freda Patterson

Enrollment

30 participants

Start Date

Jul 22, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study is to learn how exercise timing affects blood pressure in adults with elevated or high blood pressure. Exercise can influence the body's natural 24-hour rhythms, including blood pressure patterns. A single exercise session can lower blood pressure for up to 24 hours, but it is not fully understood how the time-of-day for exercise affects this response. The main question this study aims to answer is: • When the same participant exercises at different times of day (morning, afternoon, or evening), how does this affect the participant's blood pressure over the next 24 hours? Participants will: * Undergo an in-lab assessment of individual biological rhythm that will indicate the clock-time for an individual's biological night * Complete 3 supervised treadmill exercise sessions * 1 in the biological morning (biological night + 10 hours) * 1 in the biological afternoon (biological night + 15 hours) * 1 in the biological evening (biological night + 20 hours) * Complete a 24-hour blood pressure assessment before and after each exercise session


Eligibility

Min Age: 18 YearsMax Age: 39 Years

Plain Language Summary

Simplified for easier understanding

This study examines whether the time of day you exercise affects how much your blood pressure drops afterward. Researchers want to know if morning versus evening exercise produces different blood pressure responses in adults with mildly elevated blood pressure. **You may be eligible if:** - You are between 18 and 39 years old - Your resting blood pressure is in the elevated-normal range (between 120/80 and 139/89 mmHg) - You are not highly active (less than 300 minutes of moderate-to-vigorous activity per week) - You do not currently take medications that affect blood pressure or blood vessels - You do not smoke, use sleep aids, or work night/rotating shifts **You may NOT be eligible if:** - You have low blood pressure (below 120/80) or high blood pressure (140/90 or above) - You have a chronic illness such as heart disease, diabetes, cancer, or kidney disease - You have a sleep disorder (e.g., sleep apnea, insomnia) - You have a BMI below 18.5 or above 35 - You are pregnant or breastfeeding - You have any medical reason that prevents aerobic exercise Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALExercise

A single standardized, in-lab, 30-minute monitored treadmill exercise session


Locations(1)

University of Delaware

Newark, Delaware, United States

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NCT07049783


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