RecruitingNCT07050381

The Risk Factors Related to Rupture Flow-related Aneurysms in Posterior AVM

Risk Factors Related to Rupture Flow-related Aneurysms in Posterior Arteriovenious Malformation: A Muti-center Observentional Research.


Sponsor

The First Affiliated Hospital with Nanjing Medical University

Enrollment

200 participants

Start Date

Jun 13, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.


Eligibility

Inclusion Criteria2

  • pAVM with flow-related aneurysms were identified by DSA, and subarachnoid hemorrhage was confirmed by CT
  • No history of stroke, Marfan syndrome, polycystic kidney disease

Exclusion Criteria2

  • pAVM without flow-related aneurysms
  • Absence of clinical data

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Locations(2)

Jiangsu Province Hospital

Nanjing, Jiangsu, China

the First Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, China

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NCT07050381


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