Shunt-dependency After aSAH - Role of Early Hyperglycaemia in CSF and Blood
Shunt-dependency After Aneurysmal Subarachnoid Haemorrhage - the Role of Early Hyperglycaemia in Cerebro-spinal Fluid and Blood
Isabel Hostettler
160 participants
Mar 26, 2024
OBSERVATIONAL
Conditions
Summary
The goal of this study is to confirm the association of early increased glucose levels in cerebro-spinal fluid (CSF) and ventriculo-peritoneal-shunt (VPS)-dependency also evaluating the influence of blood glucose on VPS dependency in patients suffering from an aneurysmal subarachnoid haemorrhage (aSAH). The main questions we aim to answer are: * Is there an association of glucose levels on VPS dependency in patients requiring extra-ventricular-drain (EVD) placement for aSAH? * In addition, if there is, what is the influence the course of glucose levels has on VPS dependency? Glucose levels in CSF and serum will be measured on admission, or in case of CSF, upon EVD placement. Glucose in CSF will then be measured every day until EVD removal together with serum glucose. Follow-up will be conducted in person after 3 and 6 months.
Eligibility
Inclusion Criteria2
- years old and older
- Hospital admission due to an aneurysmal subarachnoid haemorrhage (radiological confirmation needed)
Exclusion Criteria3
- Younger than 18 years old
- Non-aneurysmal subarachnoid haemorrhage (eg. trauma, perimesencephalic subarachnoid haemorrhage, mycotic or flow-associated aneurysms)
- Previous enrolment into the current study
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Interventions
Samples for glucose in CSF will be taken upon EVD/LD placement until EVD/LD removal (within the first 14 days).
Samples for glucose in blood serum will be completed every day, for the first 14 days.
Locations(3)
View Full Details on ClinicalTrials.gov
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NCT06486909