To Evaluate the Safety and Efficacy of a Single-Use IVUS Ablation for Primary Hypertension

This trial tests a catheter-based procedure called renal denervation — which uses ultrasound energy to disrupt nerves near the kidney arteries — to help lower blood pressure in people with treatment-resistant high blood pressure (primary hypertension). A special imaging tool called IVUS (intravascular ultrasound) guides the procedure. **You may be eligible if:** - You are between 18 and 75 years old - You have confirmed primary high blood pressure - You have been on at least 2 blood pressure medications (including specific drug combinations) for at least 4 weeks, and your blood pressure remains above 150/90 in the office and 135 mmHg over 24 hours - Your kidney arteries have suitable anatomy for the procedure - You are able to understand and comply with the study requirements **You may NOT be eligible if:** - You have had a heart attack, stroke, or unstable angina within the past 3 months - You have type 1 diabetes, low standing blood pressure (orthostatic hypotension), or suspected secondary hypertension - Your kidneys are significantly damaged (eGFR below 45) - You have already had a renal denervation procedure - You are pregnant or planning to become pregnant within 6 months - You have a life expectancy of less than 1 year Talk to your doctor to see if this trial is right for you.